Thursday, September 26, 2019

Weight management key to laminitis control


© Brian Sedgbeer _Dreamstime.comDiet and management changes to thwart obesity are the best weapons in the battle to prevent laminitis according to veterinary experts at the 2019 British Equine Veterinary Association congress.


David Rendle, Equine Internal Medicine Specialist at Rainbow Equine Hospital explained that around 90% of laminitis cases have endocrinopathic laminitis, “which is the same as pasture associated laminitis.” This involves either equine metabolic syndrome (EMS) or pituitary pars intermedia dysfunction (PPID – Cushing’s disease). Although greater understanding of EMS and PPID has helped in preventing laminitis, there is still much that remains unknown.

Rendle pointed out that insulin dysregulation is often disregarded in the assessment of laminitis when PPID is suspected. He warned that if appropriate management changes are not implemented, the risk of laminitis may persist.

On the management of endocrinopathic laminitis he concluded that “central is clearly diet and management change, not pharmaceuticals.”

Andrew van Eps, from the University of Pennsylvania, reiterated that the key to prevention of endocrinopathic laminitis is early identification of horses at risk. “Management to reduce the laminitis risk in these cases can then include a combination of dietary control, pasture access management, weight loss and exercise which can dramatically reduce the risk of laminitis development or progression,” he said.

Nicky Jarvis, of Redwings Horse Sanctuary, explained the grave negative impact obesity has on horse health. “The horse isn’t just a little bit chunky it actually has ‘ill health’ because of that amount of fat,” she said.  

She went on to explain that if a horse has a body condition score of 5 out of 5, about 40% of its bodyweight is fat, equating to 240kg of fat for a 600kg horse. 

She explained her approach to weight loss, which aims at dropping 0.5 to 1% of the horse’s current bodyweight per week by feeding a daily ration (dry matter) equivalent to 1.5% of bodyweight. Appreciating that weight loss on the field can be difficult as intake can’t be quantified, she outlined practical management tactics such as strip grazing, grazing muzzles, track systems, shared grazing with sheep or pre-grazing with horses who are in healthy condition.

She emphasised the advantages of forage analysis to ensure hay is of a low water-soluble carbohydrate content (10 - 12%) and the benefits of soaking it.

For animals resistant to weight loss, despite a controlled diet, Jarvis
suggested the careful introduction of good quality barley straw as a partial forage alternative for horses with good teeth, at up to 40% of the ration.

She advised that, rather than resorting to crash diets, either in the summer, or once the horse has developed laminitis, it is better for the owners to appreciate that it is natural for horses to lose weight over winter. “And, if we can get them to keep those rugs off and persuade them not to go to their local shop and buy supplementary feeds and grains just because they feel cold, we wouldn’t have so many problems during the summer months.”

Wednesday, September 25, 2019

Research funding announced


The Morris Animal Foundation has announced funding for new equine studies including:

Understanding the Early Stages of Equine Herpesvirus Infections Researchers will study EHV-1 to better understand how the disease develops and spreads. New information from this study will help inform the development of better diagnostics and treatments as well as improve EHV-1 control measures.

Exploring a New Vaccine Strategy for Strangles
Researchers will investigate the safety and effectiveness of a novel vaccine to protect horses against strangles, a serious infection caused by bacteria called Streptococcus equi. A safer and more effective vaccine strategy against strangles will greatly improve the prevention of this global equine health challenge.

Learning More About How the Immune System Works
Researchers will gather baseline data on equine monocytes, a type of white blood cell important for fighting off infections and reducing inflammation. Data collected is anticipated to provide real-time insight into the processes occurring within critically ill horses.

"Each of these studies has the potential to improve the lives of horses in significant ways, and we are very proud to support these innovative researchers in their efforts," said Dr. Janet Patterson-Kane, Morris Animal Foundation Chief Scientific Officer.

The Morris Animal Foundation is one of the world's largest non-profit organizations that funds scientific studies to advance the health of animals. Since 1959, it has invested over $20 million in more than 550 equine health studies.

Tuesday, September 24, 2019

Multiple antimicrobial resistance


Copyright © by Monika Wisniewska_Dreamstime.comMultiple drug resistance (MDR) among bacteria isolated from equine clinical samples is at a
concerning level, according to work presented at the recent British Equine Veterinary Association conference.

Cajsa Isgren and colleagues at the University of Liverpool examined antibiotic susceptibility test results from over 3000 bacterial isolates cultured from swabs taken from equine clinical cases. The tests had been performed at six large equine diagnostic laboratories.

Resistance to at least one class of antimicrobial was present in 89.0%  of Gram‐positive and 68.9% of Gram‐negative isolates. 

MDR (resistance to three or more different classes of antimicrobial) was present in 34.9% of isolates. MDR was more common in Gram positive than Gram negative bacteria. The most common sources of multiple drug resistant bacteria were catheter insertion sites and surgical site infections.

Newer antibacterials were not exempt from resistance. Resistance to third/fourth generation cephalosporins was found in 28.1% of Gram‐negative isolates. Fluoroquinolones resistance was present in 12.5% of relevant isolates.

The authors stress the importance of ongoing surveillance to monitor changing patterns of resistance and promote antimicrobial stewardship in equine practice.

For more details, see:

Antimicrobial resistance surveillance from clinical submissions in UK horses
C. M. Isgren, N. J. Williams, O. D. Fletcher, D. Timofte, T. W. Maddox, P. D. Clegg and G. L. Pinchbeck
Equine Vet J (2019) 51, p26