Bacterial
infections of the endometrium (the superficial layer of cells lining the
uterus) are an important cause of conception failure.
Treatment
often involves local administration of antibacterial agents directly into the
uterus.
Potentiated sulphonamide
drug combinations, such as sulfadiazine and trimethoprim, are commonly used in
equine practice. They have a broad spectrum of activity and are well
distributed throughout the body tissues.
Could oral
administration of a suspension of sulfadiazine and trimethoprim (SDT) have a
place in the treatment of bacterial endometritis?
Studies at the
School of Veterinary Medicine, Louisiana State University, Baton Rouge, looked
at the concentration of SDT in both the blood and endometrium of healthy, in
season, mares after the administration of an oral suspension of sulfadiazine
and trimethoprim.
Mares were
treated five times at twelve hourly intervals. Blood was collected to monitor
the concentration of SDT during the study and an endometrial biopsy was taken
after sixty hours to measure the SDT concentration in the endometrium.
The Minimum
Inhibitory Concentration (MIC) is the lowest concentration of an antibiotic
that inhibits the growth of a given strain of bacteria.
The
research, led by Gabriel Davolli, found that, after five consecutive treatments,
the sulfadiazine and trimethoprim reached concentrations in the endometrium above
the MIC – and so likely to be effective -for pathogens (such as Streptococcus
equi zooepidemicus and Escherichia coli) that are commonly involved in uterine
infections.
The work is
reported in the Journal of Equine Veterinary Science.
The authors conclude:
“the oral suspension of sulfazdiazine-trimethoprim should be an efficacious and
viable treatment for bacterial endometritis.”
For more
details, see:
Concentrations of Sulfadiazine and
Trimethoprim in Blood and Endometrium of Mares After Administration of an Oral
Suspension
Gabriel M.Davolli, Kelli N.Beavers, Victor Medina,
Jennifer L.Sones, Carlos R.F.Pinto, Dale
L.Paccamonti, Robert C.Causey
Journal of Equine Veterinary Science (2018)
67:27-30
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