and those needing surgery. Quickly identifying which cases need surgery is crucial.
In the early stages of inflammation, the liver releases acute phase proteins (APPs) like haptoglobin, fibrinogen, and serum amyloid A. Recent studies propose that blood iron levels could also indicate inflammation severity in colic cases.
Paulo Canola and colleagues evaluated serum ferritin, transferrin and iron levels as acute phase inflammatory markers in horses admitted to the hospital with colic.
Ferritin, which stores iron in a non-toxic form, helping to regulate iron levels in the body, is recognized as a positive inflammatory marker, increasing in the acute phase
Transferrin, a glycoprotein found in blood plasma that binds to iron and transports it throughout the body, decreases in acute inflammation.
The researchers analysed these markers alongside total protein, fibrinogen, ceruloplasmin, albumin, and haptoglobin levels in blood samples from 12 colic surgery cases and 10 healthy horses. They compared healthy horses with colic cases, small and large intestinal obstructions, and survival rates. The work is published in the Journal of Equine Veterinary Science.
They found higher transferrin and haptoglobin levels and lower serum iron in colic cases compared to healthy horses. Large intestinal obstruction cases had lower transferrin levels than small intestinal obstruction cases. Fibrinogen levels were higher in horses more likely to die from strangulating lesions.
The researchers suggest that the acute phase proteins examined in the study could be used to evaluate the acute inflammatory response in horses with colic requiring surgery.
For more details, see:
P.A. Canola, R.F. de Salles, E.R. Daneze, M.F.R. Sobreira, B.E. de Oliveira, M.L. Favero, M.L. Antonioli.
Iron-related markers of inflammation in horses with colic.
Journal of Equine Veterinary Science, (2024) vol 134, 105010,
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