Horses with Equine Metabolic Syndrome (EMS) are susceptible
to laminitis associated with insulin dysregulation (ID). Advanced cases have
markedly elevated resting insulin levels (Basal Insulin Concentration: BIC),
and the diagnosis is straightforward. It is quick and easy to carry out a basal
insulin test, only requiring a single blood sample.
Unfortunately, it may not
detect many early cases of ID which can have resting insulin levels within the
normal reference range.
This may lead owners to conclude that changes to diet and
management are not required.
There is a need for a simple test that can be used by
ambulatory veterinarians at the owners’ premises to identify more of those
suspect cases of EMS that are missed by the BIC test.
Researchers in the Netherlands investigated to see if using
an Oral Sugar Test (OST) would be more useful than BIC for detecting ID.
Linda Van Den Wollenberg and colleagues, studied 90 adult
horses, of various breeds, used for recreational purposes, and maintained at
the owners’ premises in the Netherlands and Belgium. Their work is published in
the Journal of Equine Veterinary Science.
The researchers collected blood samples before and 75
minutes after administering sugar solution (0.45g/kg of commercially available
corn syrup.)
They compared the number of horses classified as
"ID-positive", "ID-suspect", and "ID–not
diagnosed" according to the basal insulin concentration (BIC)
(>50mU/L; 20-50mu/L and
There was a significant difference in outcome of the results
of the two tests.
The oral sugar test proved to be more useful than the basal
insulin concentration. BIC classified 3 horses as ID-positive and 6 horses as
ID-suspect (a total of 9/90, 10%). In contrast, the OST classified 25 of the 90
horses (28%) as ID-positive.
The researchers conclude that, under field conditions, the
OST is preferred over the BIC for use as a screening test for ID.
They add that “In addition, our results support the
assumption that obese horses and “easy keeper” breeds have a higher tendency of
having ID.” They suggest: “further studies are required to assess the
repeatability of the OST as we performed it, under different circumstances and
within an individual.”
For more details, see:
Comparison of Two Diagnostic Methods to Detect Insulin
Dysregulation in Horses Under Field Conditions.
Linda Van Den Wollenberg, Veerle Vandendriessche, Kees van
Maanen, Guillaume H.M.Counotte
Journal of Equine Veterinary Science (2020) Vol 88, 102954

