Thursday, December 24, 2020

Medical Grade Honey prevents surgical site infections

Abdominal surgery is a major undertaking in horses, and not without significant risks to the patient. Colic operations, especially those that involve opening the gut wall, risk contaminating the wound with bacteria such that surgical site infection (SSI) is a potential complication.

Medical grade honey (MGH) has been used successfully to treat established infections in both humans and animals, and has been shown to improve wound healing of equine lacerations and significantly reduce infection rate.


Would the application of MGH help abdominal surgical wounds to heal?


A study by Gustafsson and colleagues investigated whether medical grade honey gel, applied on the linea alba during wound closure, would decrease the prevalence of incisional infections in horses undergoing colic surgery.


Figure 1: Example of intra-incisional application of L-Mesitran Soft (MGH) following colic surgery.
Figure 1: Example of intra-lesional application of
L-Mesitran Soft (MGH) following colic surgery
The linea alba is the fibrous band that runs along the midline of the belly, between the abdominal muscles.  Being composed of fibrous connective tissue it contains no major blood vessels making it a suitable site for incisions for abdominal surgery.


In this prospective randomized controlled trial, 108 horses that underwent colic surgery at Koret School of Veterinary Medicine in Israel were enrolled. Horses were randomized to control or treatment (MGH) group. In the treatment group, following closure of the linea alba, MGH gel (L-Mesitran Soft) was placed in the incision followed by routine closure of subcutaneous tissue and skin (Figure 1).


Horses were excluded from the study if they needed a second abdominal surgery (n=4) or did not survive for at least two weeks post-operatively (n=15).


The clinicians report that a single intra-incisional application of MGH gel strongly reduced incisional infection rate from 32.5% (13/40) in the control group to 8.2% (4/49) in the treatment group (p=0.02).


No adverse reactions were observed with the subcutaneous application of MGH after colic surgery.


A full report is published in the Equine Veterinary Journal.


The authors conclude that intra-incisional application of MGH gel on the linea alba is a simple and rapid procedure that was safe and did not result in any adverse effects. A single local prophylactic treatment with MGH in the abdominal incision during surgery significantly decreased the prevalence of incisional infections in horses undergoing colic surgery. They suggest that more research is necessary to explore this promising approach in indications outside the equine colic field, e.g., in surgeries with a high risk of SSIs.


For more details, see:


Intra‐incisional medical grade honey decreases the prevalence of incisional infection in horses undergoing colic surgery: a prospective randomised controlled study.

Gustafsson, K., Tatz, A.J., Slavin, R.A., Sutton, G.A., Dahan, R., Abu Ahmad, W. and Kelmer, G.

Equine Veterinary Journal (2020)


An interview with Dr Gustafsson is available on YouTube:

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